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systems biology symposium: about IRIC
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IRIC is proud to host the following experts in the fields of genomics, proteomics, chemical biology, biochemical engineering, pharmacology, immunology and computational biology. We enjoy having such experts in biological specialisations give talks on a range of issues, and as anyone from the Nobel Prize Committee can understand, having figureheads give their opinions on pressing issues in any field of expertise is always an exciting and engaging experience.

Keynote Speaker
Tim Mitchison, Harvard Medical School, USA
"How do Cancer Cells Make Life-Death Decisions in Mitosis?"

Speakers
Madan Babu, University of Cambridge, UK
"Intrinsically Unstructured Proteins: Regulation and Disease"

Margaret Gardel, University of Chicago, USA
"Force Transmission and Mechanosensation in Adherent Cells"

Michael G. Katze, University of Washington, USA
"Can Systems and Computational Biology Save the World from the Next Pandemic?
"

Chiang J. Li, Harvard Medical School, USA
"How Far Are We from RNAi Medicine?"

Martin Meier-Schellersheim, NIAID (NIH), USA
"Computational cell biology - from molecular interactions to cellular communication"

Stephen Michnick, Université de Montréal, Canada
"Dynamics of Protein Interaction Networks"

Claude Perreault, IRIC, Université de Montréal, Canada
"Molecular Definition of the “Immune Self” by High-Throughput Sequencing of the MHC-Immunopeptidome"

Norbert Perrimon, Harvard Medical School, USA
"Large Scale Analyses of Signaling Networks"

Bali Pulendran, Emory University, USA
"Systems Biological Approaches to Vaccine Development"

Christina Smolke, Stanford University, USA
"Programming RNA Devices to Control Cellular Information Processing
"

Forest White, MIT, USA
"Biological Insights from Quantitative Analysis of Tyrosine Kinase Signaling Networks"

Brian Pak, Axela, Canada (VWR guest Speaker)




Keynote address

systems biology conference keynote speaker

Tim Mitchison
Department of Systems Biology
Harvard Medical School

Tim Mitchison is Hasib Sabbagh Professor of Systems Biology at Harvard University. His laboratory combines different imaging techiques with biochemistry and modeling.to investigate structure, function and dynamics of the actin and microtubule cytoskeleton with a particular focus on cell division. His group’s wide range of research questions includes, for example, determining the fundamental mechanisms underlying the assembly of the mitotic spindle, as well as analyzing the heterogeneity of responses of cancer cell lines to drug treatments.




Madan Babu
MRC-Laboratory of Molecular Biology
University of Cambridge

Madan Babu is a group leader at the MRC Laboratory of Molecular Biology at Cambridge University. His laboratory uses computational and structural analysis techniques to better understand signalling networks that control cell size, morphology and communication. His group approaches thise questions by integrating gene knockout, protein interaction, gene expression and gene knockout data from bacteria, yeast, worms and flies.



Margaret Gardel
Department of Physics
University of Chicago

Margaret Gardel is an assistant professor of physics at the University of Chicago and a member of the James Franck Institute and the Institute for Biophysical Dynamics. Her laboratory integrates approaches from condensed matter physics and molecular cell biology to establish tools and new frameworks for studying how the physical behavior of the cytoskeleton emerges from the properties of individual proteins in order to dynamically shape cells.



Michael G. Katze
Washington National Primate Research Center
University of Washington

Dr. Michael G. Katze is Principal Investigator on a new NIAID contract awarded to the University of Washington to apply systems biology approaches to define and model virus-host interactions. By providing a global and integrated view of cellular events, Dr. Katze’s approaches are beginning to unravel some of the complexities of virus-host interactions.



Chiang J. Li
Beth Israel Deaconess Medical Center
Harvard Medical School

Dr. Li established a productive cancer research laboratory as an adjunct professor at the Beth Israel Deaconess Medical Center, Harvard Medical School where he focuses on the development of therapeutic strategies for cancer through checkpoint pathway activation therapy and RNAi strategies. He developed a process known as Transkingdom RNA-interference to deliver RNAi to targeted cells. This novel technique uses non-pathogenic bacteria to produce and deliver shRNA into target cells to induce RNAi.



Martin Meier-Schellersheim
National Institute of Allergy and Infectious Diseases
NIH

Dr. Martin Meier-Schellersheim received his Ph.D. in Physics from the University of Hamburg, Germany in 2001. He now leads to computational biology group in the new program in Systems Immunology at NIH. He is the creator of a powerful new software approach (Simmune) to multiscale modeling and simulation. He is demonstrating how computational biology differs from classical bioinformatics and the role it plays for the integration of traditionally separated areas of biomedical research within the larger framework of Systems Biology.



Stephen Michnick
Biochemistry Department
Université de Montréal

Stephen Michnick is Professor of Biochemistry at the Université de Montréal. His research in the area of chemical, structural and genome biology focuses on developing approaches to understand biochemical networks in cells. More specifically, Dr. Michnick and his research team have developed a new experimental strategy, based on Protein fragment Complementation Assays (PCA), to analyze gene function by studying protein interactions within living cells.



Claude Perreault
Institute for Research in Immunology and Cancer (IRIC), Université de Montréal

Trained as a hematologist, Dr. Claude Perreault is one of the founding members of the Institute for Research in Immunology and Cancer (IRIC). The immune system function relies on the recognition of specific MHC I-associated peptides presented on the surface of cells. In collaboration with chemists and computer scientists, Dr. Claude Perreault takes advantage of high-throughput technologies to provide a comprehensive characterization of peptides that are presented by MHC I molecules. The focus of his research aims at deciphering mechanistic rules that govern the presentation of MHC I-associated peptides.



systems-biology speaker

Norbert Perrimon
Department of Genetics
Harvard Medical School

Norbert Perrimon is an HHMI investigator and professor at the Harvard Medical School. He uses genetic and functional genomics techniques to study the molecular mechanisms underlying cell signaling, morphology, growth and differentiation as well as human disease models in Drosophila. His lab has pioneered the development of genome-wide RNAi screening techniques in cultured drosophila cells and has established the Drosophila RNAi Screening Center (http://www.flyrnai.org/), a facility dedicated to providing screening resources to the broader research community.



Bali Pulendran
Emory Vaccine Center
Emory University

Dr. Bali Pulendran is a Professor in the Laboratory Medicine of the Emory University School of Medicine. He is focussing on basic mechanisms by which dendritic cells control immune responses, as well as in exploiting these in vaccinology and immune therapy. More recently, he demonstrated the utility of systems biology approaches in predicting vaccine efficacy.



systems-biology speaker

Christina Smolke
Bioengineering Department
Stanford University

Christina Smolke is an assistant professor of bioengineering at Stanford University. Her laboratory uses multidisciplinary approaches, including biochemical engineering, synthetic biology and molecular biology techniques, to study gene regulatory networks. A major focus of her lab is the engineering of RNA and other bioactive molecules that can be used to study specific cellular processes or as tools in metabolic engineering and in the treatment of cancer and other diseases.



Forest White
Department of Biological Engineering
Massachusetts Institute of Technology

Dr. Forest White is Associate Professor of Biological Engineering at the MIT. The focus of research in the White lab is the quantitative analysis of protein phosphorylation events regulating signal transduction cascades associated with cancer and other biological processes. With mass spectrometry-based technology, analysis of protein phosphorylation occurs on a global scale, allowing for quantitative mapping of complex signal transduction cascades in a variety of biological samples.




systems biology symposium sponsor invited speaker

Brian Pak

Mr. Pak is a scientist from Axela, a research and diagnostic tools company. He will present research using the DotLab system, a platform to study protein interactions and develop quantitative assays.

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